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Clinical, Cosmetic and Investigational Dermatology, 10 , 147

Lancet 390 , 21832193 (2017)

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EVs-mediated regulation of arginine metabolism Beyond being a component of multiple proteins, arginine, a non-essential amino acid and conditionally essential amino acid for the human body, constitutes a precursor for NO, urea, polyamines, and gamma-aminobutyric acid (GABA) [130]

Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2